Detailed monitoring of the cellular effects by innovative immune modulatory treatments is crucial. This is due to several reasons, namely the high complexity of the immune system and associated risk of setting up the wrong hypotheses, the increased requirements from regulatory authorities for pushing new immune therapies forward and the need for choosing the right combination treatment in a future trial.
We can deliver such monitoring and mechanism-of-action analyses using our multicolor flow cytometry assays. We tailor every study after carefully inspecting our customer’s needs. We enjoy equally setting up in vitro model systems using our in-house library of healthy donor material or investigating pre-clinical or clinical samples. Multicolor flow cytometry offers the possibility of a data-rich single-cell resolution characterization of treatment impact. This includes measuring in parallel multiple cell populations in regard to frequency, functionality and maturation/activation status along with also assessing minute frequencies of for instance antigen-specific T cells. Multicolor flow cytometry is thus very well suited for both immune monitoring and mechanism-of-action analyses.
Mechanism-of-action analyses and identification of new targets using innovative T cell epitope discovery platforms
We provide detailed immune monitoring using cell culturing and advanced multicolor flow cytometry. We obtain frequency and functionalilty of multiple subsets of both lymphocytes such as T cells, NK cells and B cells and antigen-presenting cell populations such as dendritic cells and monocytes
Training in the above methods.
Whether you are in need of advice for setting up new immune analyses based on flow cytometry or general scientific sparring we can help you. We also perform protocol development and optimization, making it easy for you to take in-house afterwards as well as interviews with key opinion leaders, market investigations on new devices and other "behind-the-desk" projects.